The construction sector is responsible for 50% of all material flows and 40% of the waste production worldwide. Concrete is still unmistakably the most used manmade material in the world, yet it comes with a huge environmental impact. To make the building industry more sustainable and future proof, it is crucial to develop innovative structural systems that are resource-efficient and designed to become part of a circular approach whereby components can be disassembled and reused. This SRP programme’s originality lies in the focus on load-bearing circular concrete structures made of material-efficient components and reversible connections, enabling maximum reconfiguration potential and minimum impact. Striving for maximum structural performance often results in complex geometries which are hard to manufacture. The optimization seeked for in this programme is therefore multi-objective: to design components that do not only optimally use materials, but also allow ease of fabrication, connection, and monitoring during the service life as well as qualification before their re-use. This goal can be achieved by developing a holistic design approach that involves material innovation, digital design and modelling tools, contemporary fabrication methods, reversible loadbearing connections and state-of-theart health monitoring techniques. This ambitious scientific objective can only be met by joining forces and combining our complementary expertise within a strong multidisciplinary team from both ARCH and MeMC departments at VUB.