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Detection of early left ventricular dysfunction in diabetes: application of myocardial velocity imaging to a small animal model

donderdag, 17 december, 2009 - 17:30
Campus: Brussels Health Campus
Faculteit: Medicine and Pharmacy
auditorium P. Brouwer
Caroline Weytjens
doctoraatsverdediging

The thesis evaluates the value of non-invasive
cardiac imaging techniques in the diagnosis of
early left ventricular (LV) dysfunction in diabetes.

- In a clinical study we were able to demonstrate,
from an early stage, subtle changes in diastolic
function and LV adaptation to dobutamine
stimulation with the use of transthoracic
echocardiography and MIBI gated SPECT in
humans with type 1 diabetes.
- During experimental studies, we evaluated a
more recently developed imaging technique
called myocardial velocity and deformation
imaging, in the quantification of regional LV
function in rats. With this technique we were able
to detect, before the onset of a reduced global LV
function, alterations in LV function in a rat model
with streptozotocin induced diabetes. After
excluding myocardial fibrosis, and by applying
MIBG-SPECT imaging on this model, we also
demonstrated a possible role of cardiac
autonomic neuropathy in the pathogenesis of
diabetic cardiomyopathy.

These findings should be a step forward in the
non-invasive quantification of LV function in
rodents. Myocardial velocity and deformation
imaging should in the future be used to evaluate
the effect of therapeutical interventions able to
prevent or reverse myocardial disease in
diabetes.