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The Clinical Reproductive Outcome of Preimplantation Genetic Diagnosis

dinsdag, 22 juni, 2010 - 17:00
Campus: Brussels Health Campus
Faculteit: Medicine and Pharmacy
auditorium P. Brouwer
Willem Verpoest
doctoraatsverdediging

Preimplantation genetic diagnosis (PGD) is a
technique that allows genetic selection of
embryos prior to pregnancy, with the aim of
avoiding transmission of hereditary disorders in
the offspring. The technique was applied for the
first time in humans in 1990, and has developed
at UZ Brussel since 1992. There are currently
over 100 genetic conditions that can be
diagnosed by PGD.

The research topic of the thesis is the clinical
reproductive outcome of PGD, the factors that
affect the outcome and the potential risks that
are associated with this practice. The research
methodology includes the application of life table
analysis to assess cumulative live birth rate
following PGD and multivariate regression
analysis within this application, in a large cohort
of PGD treatment cycles performed over 15 years
of PGD practice. The strengths and weaknesses
of this methodology in reproductive medicine and
PGD are discussed extensively in the thesis.

Furthermore, the thesis presents an important
subgroup analysis of the reproductive outcome of
couples undergoing PGD for myotonic dystrophy
type I (DM1), a disorder that is known to be
associated with reproductive as well as obstetric
issues.

The risk of monozygotic twinning in PGD is
analysed, and the risks of perinatal complications
are discussed. Current clinical reproductive
practices such as single embryo transfer (SET)
and ovarian stimulation in PGD are analysed.