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Spermatogonial stem cells as a source for fertility preservation and regenerative medicine

maandag, 19 september, 2011 - 17:00
Campus: Brussels Health Campus
Faculteit: Medicine and Pharmacy
auditorium R. Vanden Driessche
Liang Ning
doctoraatsverdediging

Banking and transplantation of spermatogonial
stem cells (SSCs) may become a promising
method to preserve the fertility of prepubertal
patients. According to recent studies, the
potential of SSCs to de-differentiate into
pluripotent cells or transdifferentiate into other
cell types is feasible and may become an
additional indication for spermatogonial stem cell
banking.

In our first study, we searched for an efficient
and clinically feasible method for transfusing cell
suspensions into the seminiferous tubules of
isolated human testes. We concluded that a
single ultrasound-guided injection of 800 ìl in the
rete testis may provide a promising method to
transplant human SSCs in a clinical setting.

In our second study, GFP+ mesenchymal stem
cells (MSCs) were transplanted into the testes of
GFP- recipients. Sixteen weeks posttransplantation,
MSC-transplanted testes showed
more spermatogenesis and donor-derived cells
expressed the surface markers of testicular
somatic cells. These results may indicate the
differentiation potential of murine MSCs into the
cells contributing to the stem cell niche after
transplantation. Co-transplantation of MSCs may
thus be useful for spermatogenesis reinitiation.
In our third study, we showed that intra-bone
marrow transplanted mouse SSCs have the
potential to differentiate into haematopoietic
cells.

In general, SSCs are a potential source for
fertility preservation and regenerative medicine
but more research is needed before any clinical
application can be established.

Bijlage: 
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