Key questions to be tackled by the course

• What are the key points of Regulation EC 1223/2009?
• What rules apply for borderline products?
• What are the current challenges in safety assessment of cosmetics in the EU?
• Which role does risk perception play in our society and how does it affect the cosmetic industry?
• What are animal-free alternative methods? What are NAMs?
• What validated replacement tests do we actually have? How to interpret the results?
• How to integrate in chemico, in silico and in vitro data with historical in vivo data into a PIF?
• What in silico methodology is available that is useful in safety assessment of cosmetics and their ingredients?  
• Which role does local toxicity testing play in the safety assessment of cosmetics?
• Which role does systemic toxicity testing play in the safety assessment of cosmetics? 
• What is NGRA? How to apply this new methodology for the assessment of long-term toxicity of cosmetic ingredients? 
• How to apply NGRA for the assessment of skin sensitization of a cosmetic ingredient? 
• How to deal with nanoparticles in cosmetic products?
• How to make a PIF for a finished cosmetic product according to the actual EU Regulation?
• How to make a complete dossier for a cosmetic ingredient to be taken up in the Annexes of the Regulation?
• What are the packaging requirements under Annex I?
• How to practically use the Notes of Guidance of the Scientific Committee on Consumer Safety (SCCS)?